MicroRNA-21 in the pathogenesis of acute kidney injury

The Pathogenesis of Acute Kidney Injury

Acute kidney injury (AKI) is common in critically ill patients affecting 20 60% of patients (Chertow, et al., 2005; de Mendonca, et al., 2000; Mehta, et al., 2005; Ostermann & Chang, 2008; Silvester, et al., 2001; Uchino, et al., 2005). The exact incidence varies depending on patient population, associated comorbid factors and criteria used to define AKI. Sepsis induced AKI accounts for approxi...

MicroRNAs in Pathogenesis of Acute Kidney Injury.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression mainly by repressing their target gene translation. A large spectrum of human diseases is associated with significant changes in miRNAs. Many miRNAs are induced in diseases, whereas some others are downregulated. The significance of miRNAs has been demonstrated in renal development and physiology, and in major kidney dis...

Role of leukocytes in the pathogenesis of acute kidney injury

MicroRNA-21 and Risk of Severe Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery

BACKGROUND Severe acute kidney injury (AKI) after cardiac surgery is associated with poor clinical outcomes. This study evaluated the potential use of miR-21 as a risk marker for postoperative AKI progression and other poor outcomes. METHODOLOGY/PRINCIPAL FINDINGS The study included 120 adult patients undergoing cardiac surgery: 40 non-AKI controls, 39 patients with progressive AKI, and 41 wi...

Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury.

MicroRNAs (miRNAs) are endogenous noncoding RNA molecules that are involved in post-transcriptional gene silencing. Using global miRNA expression profiling, we found miR-21, -155, and 18a to be highly upregulated in rat kidneys following tubular injury induced by ischemia/reperfusion (I/R) or gentamicin administration. Mir-21 and -155 also showed decreased expression patterns in blood and urina...